Microfaradaic Electrochemical Biosensors for the Study of Anticancer Action of DNA Intercalating Drug: Epirubicin

In the past two decades chemically modified electrodes (CME) have attracted considerable interest of researchers to exert a direct control over the chemical nature of electrodes. CMEs have found a large number of useful applications in different fields viz. selective electroorganic synthesis, biomedical analysis, electro analyses etc. The ability to manipulate the molecular architecture of bulk matrix of the electrode, particularly its surface has led to a wide range of analytical applications of CMEs and created opportunities for electroanalysts to fabricate useful biosensors The CMEs have shown remarkable specificity for biological recognition processes which has led to the development of highly selective biosensing devices. The electrochemical biosensors hold a leading position among the bioprobes currently available and hold great promise for the tasks of study of in-vivo mechanism of action of large number of drugs. These electrochemical biosensors consist of two components (1) a biological entity that recognises the target analyte and (2) the electrode transducer that translates the biorecognition event in to a useful electrical signal. Modern methods of analysis specially designed for drug discovery are mostly high-through put systems. The target samples are either obtained by natural origin generated by combinational chemistry or produced by biochemical methods. Hundreds and thousands of synthetic compounds are available in modern substance libraries, which have to be tested individually for their use as useful drugs. In addition to this, some natural resources including tropical rain forests and marine environments are of great interest for the development of potential new drugs. In the past, a large number of plants and samples obtained from biological sources of these habitats have been used as traditional medicine of native population. Scientific knowledge about these traditional medicines has attracted the attention of scientists working in the field of development of nature derived drugs.